Flumedroxone

Flumedroxone

Systematic (IUPAC) name
(2R,8S,14S,15S)-14-acetyl-14-hydroxy-2,15-dimethyl-8-(trifluoromethyl)tetracyclo[8.7.0.0^2,7.0^11,15]heptadec-6-en-5-one
Identifiers
CAS Number	987-18-8
ATC code	N02CB01 (WHO)
PubChem	CID 71881
ChemSpider	16736667
UNII	K80185F39X
ChEMBL	CHEMBL2104932
Synonyms	(6S,10R,13S,17S)-17-acetyl-17-hydroxy-10,13-dimethyl-6-(trifluoromethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 17-Acetyloxy-6α-(trifluoromethyl)preg-4-ene-3,20-dione
Chemical data
Formula	C22H29F3O3
Molar mass	398.459 g/mol
SMILES CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)C(F)(F)F)C)O
InChI InChI=1S/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1 Key:CDZJOBWKHSYNMO-SCUQKFFVSA-N
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Flumedroxone is a corticosteroid derivative used to treat migraines. In one study, the benefit was largely limited to women with headache associated with premenstrual syndrome.^[1]

References

1. Bradley WG, Hudgson P, Foster JB, Newell DJ (August 1968). "Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine". Br Med J 3 (5617): 531–3. doi:10.1136/bmj.3.5617.531. PMC 1986487. PMID 4877801.