Fluorothreonine transaldolase

Fluorothreonine transaldolase
Identifiers
EC number	2.2.1.8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a fluorothreonine transaldolase (EC 2.2.1.8) is an enzyme that catalyzes the chemical reaction

L-threonine + fluoroacetaldehyde $\rightleftharpoons$ acetaldehyde + 4-fluoro-L-threonine

Thus, the two substrates of this enzyme are L-threonine and fluoroacetaldehyde, whereas its two products are acetaldehyde and 4-fluoro-L-threonine.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). The systematic name of this enzyme class is fluoroacetaldehyde:L-threonine aldehydetransferase.

References

• Murphy CD, O'Hagan D, Schaffrath C (2001). "Identification of a PLP-Dependent Threonine Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomyces cattleya This work was supported by the Biotechnological and Biological Sciences Research Council and the University of St Andrews". Angew. Chem. Int. Ed. Engl. 40 (23): 4479–4481. doi:10.1002/1521-3773(20011203)40:23<4479::AID-ANIE4479>3.0.CO;2-1. PMID 12404452.
• Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya". Chemosphere. 52 (2): 455–61. doi:10.1016/S0045-6535(03)00191-7. PMID 12738270.