Flutemetamol (18F)

Flutemetamol (¹⁸F)
Systematic (IUPAC) name

2-[3-(¹⁸F)Fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol
Clinical data
Trade names	Vizamyl
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: C (Risk not ruled out)
Legal status	US: ℞-only
Routes of administration	Intravenous
Identifiers
ATC code	V09AX04
PubChem	CID 15950376
ChemSpider	13092196
UNII	0F3M7032P5
ChEBI	CHEBI:76611
Chemical data
Formula	C₁₄H₁₁¹⁸FN₂OS
Molar mass	273.316 g/mol
SMILES CNC1=C(C=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O)[18F]
InChI InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3/i15-1 Key:VVECGOCJFKTUAX-HUYCHCPVSA-N

Flutemetamol (¹⁸F) (trade name Vizamyl, by GE Healthcare) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18, used as a diagnostic tool for Alzheimer's disease.^[1]

Mechanism of action

After the substance is given intravenously, it accumulates in beta amyloid plaques in the patient's brain, which thus become visible via positron emission tomography (PET).^[1]

References

1 2 H. Spreitzer (18 August 2014). "Neue Wirkstoffe – Flutemetamol". Österreichische Apothekerzeitung (in German) (17/2014): 43.

Diagnostic radiopharmaceuticals (V09)

Central nervous system	^99mTc (Exametazime) ¹²³I (Ioflupane Iofetamine Iomazenil) ¹⁸F (Florbetapir, Flutemetamol)

Skeletal system	^99mTc (Medronic acid)

Renal	¹²³I (Sodium iodohippurate) ⁶⁴Cu (Cu-ETS2)

Hepatic/reticuloendothelial	⁷⁵Se (SeHCAT)

Respiratory system	¹³³Xe ^81mKr

Cardiovascular system	^99mTc (Sestamibi Tetrofosmin) ¹¹¹In (Imciromab) ⁸²Rb (Rubidium chloride)

Inflammation/infection	^99mTc (Exametazime Sulesomab Tilmanocept) ¹¹¹In ⁶⁷Ga

Tumor	^99mTc (Arcitumomab Votumumab Hynic-octreotide) ¹¹¹In (Capromab pendetide Satumomab pendetide) ¹²⁵I ( Minretumomab) ¹²³I/¹³¹I (Iobenguane) ¹⁸F (Fludeoxyglucose Sodium fluoride)

Adrenal cortex	¹²³I/¹²⁵I (Iodocholesterol)

Radionuclides (including tracers)	positron (PET): ¹⁸F ¹¹C ⁶⁴Cu ¹³N ¹⁵O ⁶⁸Ga gamma ray/photon (SPECT/scintigraphy): ^99mTc ¹²³I ¹²⁵I ¹³¹I ¹¹¹In ⁵⁷Co ¹⁵³Sm ¹³³Xe ⁵¹Cr ^81mKr ²⁰¹Tl ⁶⁷Ga ⁷⁵Se

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