Frédéric Triebel

This article is about the French immunologist. For other uses, see Triebel (disambiguation).
Frédéric Triebel
Born (1954-11-20) 20 November 1954
Douala, Cameroon
Nationality French
Fields Immunology, Translational medicine
Institutions Institut Gustave Roussy, University of Paris XI, Immutep, Prima BioMed
Known for Discovering LAG-3

Frédéric Triebel (born 20 November 1954) is a French immunologist who is best known for his 1990 discovery of the LAG3 immune control mechanism. Triebel worked through the 1990s in a collaboration between Institut Gustave Roussy and Merck Serono to establish LAG-3’s mechanism of action in T cells and dendritic cells. In 2001 he founded Immutep SA, a biotech company, to develop the therapeutic potential of LAG3. In 2014 this company was acquired by Prima BioMed,[1] where Triebel remains Chief Scientific and Medical Officer.

Early life and education

Frédéric Triebel was born in Douala, Cameroon, to Marcel and Odette Triebel.[2] He completed his Doctor of Medicine degree at Poitiers University in 1981 and then a four-year clinical hematology fellowship in Paris hospitals. In 1983, Frédéric Triebel received the Gold Medal of the Paris Medicine University.[3] In parallel, Triebel gained a PhD in Immunology at the University of Paris VI in 1985. His PhD thesis was in the field of immunogenetics, focused on the mechanisms that activate human antigen-specific T-cells.[4]

Career

From 1986 until the late 1990s, Triebel headed the cellular immunology group in the Department of Clinical Biology of the Institut Gustave Roussy. In 1990 he gained a Chair in Molecular Immunogenetics and Biotherapy at the University of Paris XI. Between 1991 and 1996 was director of an INSERM unit (U333). He founded Immutep SA in 2001 in order to develop the clinical potential of LAG3 and stayed with this company through to its acquisition by Prima BioMed in 2014. Triebel remains Chief Scientific and Medical Officer of Prima BioMed.

From 1993 to 1998, Frédéric Triebel was appointed as member of the Institut Universitaire de France.[5]

Work on LAG3 prior to 2001

Triebel reported the first cloning of the LAG3 gene in 1990,[6] and two years later his team were able to show that the LAG-3 protein was a ligand for MHC Class II molecules like CD4.[7] In 1997 the Triebel lab identified the LAG-3 amino-acid residues involved in LAG-3/MHC class II interaction.[8] In 1998 Triebel et al. performed the first characterization of the human CD4/LAG-3 gene locus, in the process identifying the LAG-3 promoter regulatory elements.[9] Also in 1998 the Triebel team were the first to characterizing the negative regulatory role of LAG-3 on CD3/TCR signaling.[10] His team was the first to show that, as a soluble molecule, LAG-3 activates antigen-presenting cells through MHC class II signalling, resulting in antigen-specific T-cell responses.[11] Soluble LAG3, in a dimeric recombinant form called LAG-3Ig is now Prima BioMed's lead compound.

Immutep

Frédéric Triebel founded Immutep in 2001 with John Hawken, a bioentrepreneur, to acquire the intellectual property which Triebel had created with INSERM and the Institut Gustave Roussy related to LAG3 and then move LAG3-based products into the clinic. Serono granted an exclusive worldwide license. The company raised €2.5m in venture capital in late 2003[12] and another €2.5m in January 2005.[13] Between 2001 and 2014 Immutep scientists did further basic and applied research on LAG3 and also completed a number of clinical studies, most notable in metastatic renal cell carcinoma in 2009[14] and metastatic breast cancer in 2010.[15] Immutep was sold to Prima BioMed in 2014 for US$25m.[16]

Distinctions

References

  1. ↑ "Prima Announces Immutep's IMP321 Patent Application Receives Australian Notice of Allowance" (PDF). Primabiomed.com.au. Retrieved 2015-04-30.
  2. ↑ "Frédéric Triebel (born November 20, 1954), Cameroonian immunologist". Prabook.org. 1954-11-20. Retrieved 2015-04-30.
  3. ↑ "AAIHP - Les médailles d'or".
  4. ↑ "Professor Frédéric TRIEBEL". Immunology.free.fr. Retrieved 2015-04-30.
  5. ↑ http://www.legifrance.gouv.fr/affichTexte.do?cidTexte=JORFTEXT000000530291
  6. ↑ Triebel, F; Jitsukawa, S; Baixeras, E; Roman-Roman, S; Genevee, C; Viegas-Pequignot, E; Hercend, T (1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". The Journal of Experimental Medicine 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078.
  7. ↑ Baixeras, E; Huard, B; Miossec, C; Jitsukawa, S; Martin, M; Hercend, T; Auffray, C; Triebel, F; Piatier-Tonneau, D (1992). "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine 176 (2): 327–37. doi:10.1084/jem.176.2.327. PMC 2119326. PMID 1380059.
  8. ↑ Huard, B; Mastrangeli, R; Prigent, P; Bruniquel, D; Donini, S; El-Tayar, N; Maigret, B; Dréano, M; Triebel, F (1997). "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein". Proceedings of the National Academy of Sciences of the United States of America 94 (11): 5744–9. doi:10.1073/pnas.94.11.5744. PMC 20850. PMID 9159144.
  9. ↑ Bruniquel, D; Borie, N; Hannier, S; Triebel, F (1998). "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II". Immunogenetics 48 (2): 116–24. doi:10.1007/s002510050411. PMID 9634475.
  10. ↑ Hannier, S; Tournier, M; Bismuth, G; Triebel, F (1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling". Journal of immunology 161 (8): 4058–65. PMID 9780176.
  11. ↑ Triebel, F (2003). "LAG-3: A regulator of T-cell and DC responses and its use in therapeutic vaccination". Trends in immunology 24 (12): 619–22. doi:10.1016/j.it.2003.10.001. PMID 14644131.
  12. ↑ "Immutep Closes Funding to develop Novel Therapeutic Vaccines" (PDF). Immutep.com. Retrieved 2015-04-30.
  13. ↑ "Immutep Closes Second Funding to Enter Clinic" (PDF). Immutep.com. Retrieved 2015-04-30.
  14. ↑ Brignone C, Escudier B, Grygar C, Marcu M, Triebel F. (October 1, 2009). "A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma.". J Clin Cancer Res. 15 (19): 6225–31. doi:10.1158/1078-0432.CCR-09-0068. PMID 19755389.
  15. ↑ Brignone C, Gutierrez M, Mefti F, Brain E, Jarcau R, Cvitkovic F, Bousetta N, Medioni J, Gligorov J, Grygar C, Marcu M, Triebel F (July 23, 2010). "First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity". J Transl Med. 8 (71). doi:10.1186/1479-5876-8-71. PMC 2920252. PMID 20653948.
  16. ↑ "Prima Biomed". Primabiomed.com.au. 2014-12-17. Retrieved 2015-04-30.
  17. ↑ "AAIHP - Les médailles d'or".
  18. ↑ http://www.cnrs.fr/insb/recherche/prix/2007/PrixFRM2007.pdf
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