Ftx (gene)

FTX transcript, XIST regulator (non-protein coding)
Identifiers
Symbols FTX ; LINC00182; MIR374AHG; NCRNA00182
External IDs OMIM: 300936 GeneCards: FTX Gene
Orthologs
Species Human Mouse
Entrez 100302692 n/a
Ensembl ENSG00000230590 n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr X:
73.96 – 74.29 Mb		 n/a
PubMed search n/a

In molecular biology, FTX transcript, XIST regulator (non-protein coding), also known as FTX (Five prime to Xist), is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the XIST gene.[1] FTX contains several microRNAs within its introns.[2] It upregulates expression of XIST, and inhibits DNA methylation of the XIST promoter. [2]

See also

References

  1. ↑ Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L; et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine.". Genome Res 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731. PMID 12045143.
  2. 1 2 Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P; et al. (2011). "Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.". Hum Mol Genet 20 (4): 705–18. doi:10.1093/hmg/ddq516. PMID 21118898.
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