Functional analog (chemistry)

In chemistry and pharmacology, functional analogs are chemical compounds that have similar physical, chemical, biochemical, or pharmacological properties. Functional analogs are not necessarily also structural analogs with a similar chemical structure.[1] An example of pharmacological functional analogs are morphine, heroine and fentanyl, which have the same mechanism of action, but fentanyl is structurally quite different from the other two.[2]


References

  1. ↑ Martin, Yvonne C.; Kofron, James L.; Traphagen, Linda M. (2002). "Do Structurally Similar Molecules Have Similar Biological Activity?". Journal of Medicinal Chemistry 45 (19): 4350. doi:10.1021/jm020155c. PMID 12213076.
  2. ↑ Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 214f, 286. ISBN 3-8047-1763-2.
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