Fusion transcript

Fusion transcript is a chimeric RNA encoded by a fusion gene[1] or by two different genes by subsequent trans-splicing.[2][3] Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.

References

  1. ↑ Mitelman; Johansson, B; Mertens, F (2007). "The impact of translocations and gene fusions on cancer causation". Nature reviews. Cancer 7 (4): 233–45. doi:10.1038/nrc2091. PMID 17361217.
  2. ↑ Li; Wang, J; Mor, G; Sklar, J (2008). "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells". Science 321 (5894): 1357–61. doi:10.1126/science.1156725. PMID 18772439.
  3. ↑ Rickman, F; Pflueger, D; Moss, B; Vandoren, VE; Chen, CX; De La Taille, A; Kuefer, R; Tewari, AK; et al. (2009). "SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer". Cancer Research 69 (7): 2734–8. doi:10.1158/0008-5472.CAN-08-4926. PMID 19293179.
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