Gamma-guanidinobutyraldehyde dehydrogenase

gamma-guanidinobutyraldehyde dehydrogenase
Identifiers
EC number	1.2.1.54
CAS number	56831-75-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a gamma-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) is an enzyme that catalyzes the chemical reaction

4-guanidinobutanal + NAD⁺ + H₂O $\rightleftharpoons$ 4-guanidinobutanoate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-guanidinobutanal, NAD⁺, and H₂O, whereas its 3 products are 4-guanidinobutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-guanidinobutanal:NAD+ 1-oxidoreductase. Other names in common use include alpha-guanidinobutyraldehyde dehydrogenase, 4-guanidinobutyraldehyde dehydrogenase, and GBAL dehydrogenase. This enzyme participates in urea cycle and metabolism of amino groups.

References

• Yorifuji T, Koike K, Sakurai T and Yokoyama K (1986). "4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida". Agric. Biol. Chem. 50: 2009–2016. doi:10.1271/bbb1961.50.2009.