G3BP1

GTPase activating protein (SH3 domain) binding protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols G3BP1 ; G3BP; HDH-VIII
External IDs OMIM: 608431 MGI: 1351465 HomoloGene: 38096 GeneCards: G3BP1 Gene
EC number 3.6.4.12, 3.6.4.13
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10146 27041
Ensembl ENSG00000145907 ENSMUSG00000018583
UniProt Q13283 P97855
RefSeq (mRNA) NM_005754 NM_013716
RefSeq (protein) NP_005745 NP_038744
Location (UCSC) Chr 5:
151.77 – 151.81 Mb
Chr 11:
55.47 – 55.5 Mb
PubMed search

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.[1][2][3]

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]

Interactions

G3BP1 has been shown to interact with USP10.[5] It also interacts with SND1[5].

References

  1. Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol 16 (6): 2561–9. PMC 231246. PMID 8649363.
  2. Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
  3. 1 2 "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
  4. Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLoS ONE 6 (12): e29024. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
  5. Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene (England) 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350.

[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.

Further reading

External links


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