GAIN domain

GPCR-Autoproteolsis INducing (GAIN) domain, rat latrophilin 4DLQ​ mediates autocatalytic cleavage of adhesion GPCRs

The GAIN domain (G-protein-coupled receptor (GPCR) autoproteolysis-inducing domain) is a protein domain found in a number of cell surface receptors, including adhesion-GPCRs and polycystic kidney disease proteins PKD1 and PKD2. The domain is involved in the self-cleavage of these transmembrane receptors, and has been shown to be crucial for their function . Point mutations within the GAIN domain of PKD1 and GPR56 are known to cause polycystic kidney disease and polymicrogyria, respectively.[1][2][3]

References

  1. ↑ Araç, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Südhof, TC; Brunger, AT (Feb 14, 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  2. ↑ Lin, HH; Chang, GW; Davies, JQ; Stacey, M; Harris, J; Gordon, S (Jul 23, 2004). "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.". The Journal of Biological Chemistry 279 (30): 31823–32. doi:10.1074/jbc.M402974200. PMID 15150276.
  3. ↑ Chang, GW; Stacey, M; Kwakkenbos, MJ; Hamann, J; Gordon, S; Lin, HH (Jul 17, 2003). "Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.". FEBS Letters 547 (1-3): 145–50. doi:10.1016/S0014-5793(03)00695-1. PMID 12860403.


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