GAL3ST1
| Galactose-3-O-sulfotransferase 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | GAL3ST1 ; CST | ||||||||||||
| External IDs | OMIM: 602300 MGI: 1858277 HomoloGene: 3574 GeneCards: GAL3ST1 Gene | ||||||||||||
| EC number | 2.8.2.11 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9514 | 53897 | |||||||||||
| Ensembl | ENSG00000128242 | ENSMUSG00000049721 | |||||||||||
| UniProt | Q99999 | Q9JHE4 | |||||||||||
| RefSeq (mRNA) | NM_004861 | NM_001177691 | |||||||||||
| RefSeq (protein) | NP_004852 | NP_001171162 | |||||||||||
| Location (UCSC) |
Chr 22: 30.55 – 30.57 Mb |
Chr 11: 3.98 – 4 Mb | |||||||||||
| PubMed search | |||||||||||||
Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.[1][2][3]
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.[3]
References
- ↑ "Toward a complete human genome sequence". Genome Res 8 (11): 1097–108. Jan 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- ↑ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
- 1 2 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".
Further reading
- Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
- Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. PMID 2562955.
- Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
- Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. PMID 5562350.
- Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086.
- Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451.
- Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
- Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
- Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMC 1222978. PMID 12175333.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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