GAL3ST3

Galactose-3-O-sulfotransferase 3
Identifiers
Symbols GAL3ST3 ; GAL3ST-3; GAL3ST2
External IDs OMIM: 608234 MGI: 3617843 HomoloGene: 57198 GeneCards: GAL3ST3 Gene
Orthologs
Species Human Mouse
Entrez 89792 545276
Ensembl ENSG00000175229 ENSMUSG00000047658
UniProt Q96A11 P61315
RefSeq (mRNA) NM_033036 NM_001024717
RefSeq (protein) NP_149025 NP_001019888
Location (UCSC) Chr 11:
66.04 – 66.05 Mb
Chr 19:
5.3 – 5.31 Mb
PubMed search

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.[1][2][3]

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3.[3]

References

  1. Suzuki A, Hiraoka N, Suzuki M, Angata K, Misra AK, McAuliffe J, Hindsgaul O, Fukuda M (Jun 2001). "Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans". J Biol Chem 276 (26): 24388–95. doi:10.1074/jbc.M103135200. PMID 11323440.
  2. El-Fasakhany FM, Uchimura K, Kannagi R, Muramatsu T (Jul 2001). "A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc". J Biol Chem 276 (29): 26988–94. doi:10.1074/jbc.M100348200. PMID 11356829.
  3. 1 2 "Entrez Gene: GAL3ST3 galactose-3-O-sulfotransferase 3".

Further reading

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