GAS2
| Growth arrest-specific 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
PDB rendering based on 1v5r. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | GAS2 ; MGC32610 | ||||||||||||
| External IDs | OMIM: 602835 MGI: 95657 HomoloGene: 31301 GeneCards: GAS2 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2620 | 14453 | |||||||||||
| Ensembl | ENSG00000148935 | ENSMUSG00000030498 | |||||||||||
| UniProt | O43903 | P11862 | |||||||||||
| RefSeq (mRNA) | NM_001143830 | NM_008087 | |||||||||||
| RefSeq (protein) | NP_001137302 | NP_032113 | |||||||||||
| Location (UCSC) |
Chr 11: 22.63 – 22.81 Mb |
Chr 7: 51.86 – 51.99 Mb | |||||||||||
| PubMed search | |||||||||||||
Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.[1][2]
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[2]
References
- ↑ Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
- 1 2 "Entrez Gene: GAS2 growth arrest-specific 2".
Further reading
- Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections". Journal of oral surgery (American Dental Association : 1965) 33 (8): 619–21. PMID 1056466.
- Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J. Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
- Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells". Cell 54 (6): 787–93. doi:10.1016/S0092-8674(88)91065-3. PMID 3409319.
- Sgorbissa A, Benetti R, Marzinotto S; et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis". J. Cell. Sci. 112 (23): 4475–82. PMID 10564664.
- Benetti R, Del Sal G, Monte M; et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMC 125501. PMID 11387205.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tsutsumi S, Kamata N, Vokes TJ; et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Benetti R, Copetti T, Dell'Orso S; et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions". J. Biol. Chem. 280 (23): 22070–80. doi:10.1074/jbc.M501810200. PMID 15817486.
| |||||||||
This article is issued from Wikipedia - version of the Wednesday, May 06, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.