GAS2L1

Growth arrest-specific 2 like 1
Identifiers
Symbols	GAS2L1 ; GAR22
External IDs	OMIM: 602128 MGI: 1926176 HomoloGene: 4733 GeneCards: GAS2L1 Gene
Gene ontology Molecular function • microtubule binding • cytoskeletal adaptor activity • thyroid hormone receptor binding Cellular component • stress fiber • cytoplasm • cytoskeleton • microtubule Biological process • microtubule bundle formation • negative regulation of microtubule depolymerization • cell cycle arrest • cellular response to starvation • negative regulation of gene expression • negative regulation of cell growth • negative regulation of erythrocyte differentiation • regulation of cell cycle • cellular response to thyroid hormone stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10634	78926
Ensembl	ENSG00000185340	ENSMUSG00000034201
UniProt	Q99501	Q8JZP9
RefSeq (mRNA)	NM_001278730	NM_001190406
RefSeq (protein)	NP_001265659	NP_001177335
Location (UCSC)	Chr 22: 29.31 – 29.31 Mb	Chr 11: 5.05 – 5.07 Mb
PubMed search

GAS2-like protein 1 is a protein that in humans is encoded by the GAS2L1 gene.^[1][2][3][4]

The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.^[4]

References

1. Zucman-Rossi J, Legoix P, Thomas G (Mar 1997). "Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region". Genomics 38 (3): 247–54. doi:10.1006/geno.1996.0625. PMID 8975699.
2. Goriounov D, Leung CL, Liem RK (Feb 2003). "Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules". J Cell Sci 116 (Pt 6): 1045–58. doi:10.1242/jcs.00272. PMID 12584248.
3. Brancolini C, Bottega S, Schneider C (Jul 1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J Cell Biol 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
4. "Entrez Gene: GAS2L1 growth arrest-specific 2 like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Weinmann AS, Yan PS, Oberley MJ; et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.