GAS7

Growth arrest-specific 7
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LX7​, 2YSH​
Identifiers
Symbols	GAS7 ; MLL/GAS7
External IDs	OMIM: 603127 MGI: 1202388 HomoloGene: 69015 GeneCards: GAS7 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein binding • actin filament binding Cellular component • ruffle • cytoplasm • actin filament Biological process • regulation of transcription, DNA-templated • cell cycle arrest • regulation of cell shape • actin filament polymerization • neuron projection morphogenesis • actin filament bundle assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8522	14457
Ensembl	ENSG00000007237	ENSMUSG00000033066
UniProt	O60861	B1ATI9
RefSeq (mRNA)	NM_001130831	NM_001109657
RefSeq (protein)	NP_001124303	NP_001103127
Location (UCSC)	Chr 17: 9.91 – 10.2 Mb	Chr 11: 67.46 – 67.69 Mb
PubMed search

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.^[1][2]

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.^[2]

References

1. Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S (Oct 1998). "gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation". Proc Natl Acad Sci U S A 95 (19): 11423–11428. doi:10.1073/pnas.95.19.11423. PMC 21658. PMID 9736752.
2. "Entrez Gene: GAS7 growth arrest-specific 7".

Further reading

• Kurtz A, Zimmer A (1995). "Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17". Mamm. Genome 6 (5): 379–380. doi:10.1007/BF00364810. PMID 7626897.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Megonigal MD, Cheung NK, Rappaport EF, et al. (2000). "Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2814–2819. doi:10.1073/pnas.050397097. PMC 16012. PMID 10706619.
• She BR, Liou GG, Lin-Chao S (2002). "Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth". Exp. Cell Res. 273 (1): 34–44. doi:10.1006/excr.2001.5435. PMID 11795944.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chao CC, Chang PY, Lu HH (2005). "Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth". J. Neurosci. Res. 81 (2): 153–162. doi:10.1002/jnr.20552. PMID 15948147.