GBF1

Golgi brefeldin A resistant guanine nucleotide exchange factor 1
Identifiers
Symbols	GBF1 ; ARF1GEF
External IDs	OMIM: 603698 MGI: 1861607 HomoloGene: 37897 GeneCards: GBF1 Gene
Gene ontology Molecular function • ARF guanyl-nucleotide exchange factor activity • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,5-bisphosphate binding Cellular component • Golgi membrane • mitochondrion • peroxisome • endoplasmic reticulum lumen • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • Golgi stack • cis-Golgi network • trans-Golgi network • lipid particle • plasma membrane • membrane • cell leading edge Biological process • cell activation involved in immune response • retrograde vesicle-mediated transport, Golgi to ER • post-Golgi vesicle-mediated transport • Golgi to endosome transport • organelle organization • Golgi organization • regulation of mitotic cell cycle • protein transport • viral process • regulation of cell adhesion • neutrophil chemotaxis • regulation of ARF protein signal transduction • protein localization to Golgi apparatus • retrograde transport, endosome to Golgi • positive regulation of GTPase activity • COPI coating of Golgi vesicle • membrane organization • establishment of monopolar cell polarity • protein localization to endoplasmic reticulum exit site • Golgi disassembly • endoplasmic reticulum-Golgi intermediate compartment organization • reactive oxygen species biosynthetic process • protein localization to endoplasmic reticulum tubular network • regulation of protein localization to cell surface Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8729	107338
Ensembl	ENSG00000107862	ENSMUSG00000025224
UniProt	Q92538	Q6DFZ1
RefSeq (mRNA)	NM_001199378	NM_178930
RefSeq (protein)	NP_001186307	NP_849261
Location (UCSC)	Chr 10: 102.25 – 102.38 Mb	Chr 19: 46.15 – 46.29 Mb
PubMed search

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.^[1][2]

References

1. Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.
2. "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Seki N, Ishikawa K; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Claude A, Zhao BP, Kuziemsky CE; et al. (1999). "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5.". J. Cell Biol. 146 (1): 71–84. doi:10.1083/jcb.146.1.71. PMC 2199737. PMID 10402461.
• Kawamoto K, Yoshida Y, Tamaki H; et al. (2003). "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.". Traffic 3 (7): 483–95. doi:10.1034/j.1600-0854.2002.30705.x. PMID 12047556.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor.". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMC 1315890. PMID 12634853.
• Claude A, Zhao BP, Melançon P (2003). "Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity.". Biochem. Biophys. Res. Commun. 303 (1): 160–9. doi:10.1016/S0006-291X(03)00316-4. PMID 12646181.
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL (2005). "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi.". Mol. Biol. Cell 16 (3): 1213–22. doi:10.1091/mbc.E04-07-0599. PMC 551486. PMID 15616190.
• Szul T, Garcia-Mata R, Brandon E; et al. (2005). "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.". Traffic 6 (5): 374–85. doi:10.1111/j.1600-0854.2005.00282.x. PMID 15813748.
• Roy SK, Hu J, Meng Q; et al. (2006). "Development of monoclonal antibodies against GBF1 and their use in studying its functions.". J. Interferon Cytokine Res. 25 (11): 666–73. doi:10.1089/jir.2005.25.666. PMID 16318580.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Zhao X, Claude A, Chun J; et al. (2006). "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic.". J. Cell. Sci. 119 (Pt 18): 3743–53. doi:10.1242/jcs.03173. PMID 16926190.
• Belov GA, Altan-Bonnet N, Kovtunovych G; et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA.". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456. PMID 17079330.