GBP1

Guanylate binding protein 1, interferon-inducible
PDB rendering based on 1dg3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1DG3​, 1F5N​, 2B8W​, 2B92​, 2BC9​, 2D4H​
Identifiers
Symbol	GBP1
External IDs	OMIM: 600411 HomoloGene: 133759 GeneCards: GBP1 Gene
Gene ontology Molecular function • actin binding • GTPase activity • protein binding • GTP binding • enzyme binding • cytokine binding • spectrin binding • identical protein binding • Hsp90 protein binding Cellular component • Golgi membrane • extracellular region • cytosol Biological process • metabolic process • cytokine-mediated signaling pathway • regulation of calcium-mediated signaling • negative regulation of T cell receptor signaling pathway • defense response to virus • interferon-gamma-mediated signaling pathway • negative regulation of ERK1 and ERK2 cascade • negative regulation of substrate adhesion-dependent cell spreading • negative regulation of interleukin-2 secretion • regulation of protein localization to plasma membrane • negative regulation of protein localization to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2633	n/a
Ensembl	ENSG00000117228	n/a
UniProt	P32455	n/a
RefSeq (mRNA)	NM_002053	n/a
RefSeq (protein)	NP_002044	n/a
Location (UCSC)	Chr 1: 89.05 – 89.07 Mb	n/a
PubMed search		n/a

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.^[1][2] It belongs to the dynamin superfamily of large GTPases.^[3]

Function

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.^[2]

References

1. Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790.
2. "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa".
3. Praefcke GJ, McMahon HT (February 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446.

Further reading

• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
• Naschberger E, Bauer M, Stürzl M (2006). "Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases.". Adv. Enzyme Regul. 45: 215–27. doi:10.1016/j.advenzreg.2005.02.011. PMID 16005050.
• Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP". Mol. Cell. Biol. 11 (9): 4717–25. PMC 361367. PMID 1715024.
• Nantais DE, Schwemmle M, Stickney JT; et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc. Biol. 60 (3): 423–31. PMID 8830800.
• Saunders NA, Smith RJ, Jetten AM (1999). "Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells". J. Invest. Dermatol. 112 (6): 977–83. doi:10.1046/j.1523-1747.1999.00611.x. PMID 10383748.
• Prakash B, Praefcke GJ, Renault L; et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature 403 (6769): 567–71. doi:10.1038/35000617. PMID 10676968.
• Kumar S, Li Q, Dua A; et al. (2001). "Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation". J. Clin. Endocrinol. Metab. 86 (6): 2420–7. doi:10.1210/jc.86.6.2420. PMID 11397834.
• Guenzi E, Töpolt K, Cornali E; et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines". EMBO J. 20 (20): 5568–77. doi:10.1093/emboj/20.20.5568. PMC 125279. PMID 11598000.
• Lubeseder-Martellato C, Guenzi E, Jörg A; et al. (2002). "Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases". Am. J. Pathol. 161 (5): 1749–59. doi:10.1016/S0002-9440(10)64452-5. PMC 1850787. PMID 12414522.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Adkins JN, Varnum SM, Auberry KJ; et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Guenzi E, Töpolt K, Lubeseder-Martellato C; et al. (2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression". EMBO J. 22 (15): 3772–82. doi:10.1093/emboj/cdg382. PMC 169055. PMID 12881412.
• Naschberger E, Werner T, Vicente AB; et al. (2004). "Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells". Biochem. J. 379 (Pt 2): 409–20. doi:10.1042/BJ20031873. PMC 1224089. PMID 14741045.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Praefcke GJ, Kloep S, Benscheid U; et al. (2004). "Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis". J. Mol. Biol. 344 (1): 257–69. doi:10.1016/j.jmb.2004.09.026. PMID 15504415.
• Modiano N, Lu YE, Cresswell P (2005). "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8680–5. doi:10.1073/pnas.0503227102. PMC 1150846. PMID 15937107.
• Ghosh A, Praefcke GJ, Renault L; et al. (2006). "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP". Nature 440 (7080): 101–4. doi:10.1038/nature04510. PMID 16511497.