GFI1B

Growth factor independent 1B transcription repressor
Identifiers
Symbols	GFI1B ; BDPLT17; ZNF163B
External IDs	OMIM: 604383 MGI: 1276578 HomoloGene: 31223 GeneCards: GFI1B Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor binding • protein binding • metal ion binding Cellular component • nucleus • transcription factor complex • nuclear matrix Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • cell proliferation • chromatin modification • myeloid cell differentiation • regulation of neurogenesis • regulation of histone H3-K4 methylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8328	14582
Ensembl	ENSG00000165702	ENSMUSG00000026815
UniProt	Q5VTD9	O70237
RefSeq (mRNA)	NM_001135031	NM_001160406
RefSeq (protein)	NP_001128503	NP_001153878
Location (UCSC)	Chr 9: 132.95 – 132.99 Mb	Chr 2: 28.61 – 28.62 Mb
PubMed search

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.^[1][2]

References

1. Rodel B, Wagner T, Zornig M, Niessing J, Moroy T (Feb 1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases". Genomics 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
2. "Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)".

Further reading

• Tong B, Grimes HL, Yang TY; et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.". Mol. Cell. Biol. 18 (5): 2462–73. PMC 110626. PMID 9566867.
• Osawa M, Yamaguchi T, Nakamura Y; et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.". Blood 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang DY, Kuo YY, Lai JS; et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene.". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMC 506805. PMID 15280509.
• Garçon L, Lacout C, Svinartchouk F; et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.". Blood 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
• Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells.". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMC 1226314. PMID 16177182.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.". Blood 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
• Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription.". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMC 1900040. PMID 17420275.