GGT6 (gene)

gamma-glutamyltransferase 6
Identifiers
Aliases	GGT6
External IDs	MGI: 1918772 HomoloGene: 51918 GeneCards: 124975
EC number	3.4.19.13
Gene ontology Molecular function • transferase activity • glutathione hydrolase activity • gamma-glutamyltransferase activity • transferase activity, transferring acyl groups • hydrolase activity Cellular component • integral component of membrane • extracellular exosome • anchored component of external side of plasma membrane • membrane Biological process • leukotriene biosynthetic process • glutathione biosynthetic process • glutathione metabolic process • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	124975	71522
Ensembl	ENSG00000167741	ENSMUSG00000040471
UniProt	Q6P531	Q6PDE7
RefSeq (mRNA)	NM_153338 NM_001122890 NM_001288702 NM_001288703 NM_001288704	NM_027819 XM_006534241 XM_006534242 XM_006534243 XM_006534244
RefSeq (protein)	NP_001116362.1 NP_001275631.1 NP_001275632.1 NP_001275633.1 NP_699169.2	NP_082095.2 XP_006534305.1
Location (UCSC)	Chr 17: 4.56 – 4.56 Mb	Chr 11: 72.44 – 72.44 Mb
PubMed search
Wikidata

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Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene. ^[1]

Function

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).

References

1. "Entrez Gene: Gamma-glutamyltransferase 6". Retrieved 2016-03-11.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.