GGTL3
| Gamma-glutamyltransferase 7 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | GGT7 ; D20S101; GGT4; GGTL3; GGTL5; dJ18C9.2 | ||||||||||||
| External IDs | OMIM: 612342 MGI: 1913385 HomoloGene: 70866 GeneCards: GGT7 Gene | ||||||||||||
| EC number | 2.3.2.2, 3.4.19.13 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2686 | 207182 | |||||||||||
| Ensembl | ENSG00000131067 | ENSMUSG00000027603 | |||||||||||
| UniProt | Q9UJ14 | Q99JP7 | |||||||||||
| RefSeq (mRNA) | NM_178026 | NM_144786 | |||||||||||
| RefSeq (protein) | NP_821158 | NP_659035 | |||||||||||
| Location (UCSC) |
Chr 20: 34.84 – 34.87 Mb |
Chr 2: 155.49 – 155.52 Mb | |||||||||||
| PubMed search | |||||||||||||
Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.[1][2][3]
Gamma-glutamyltransferase is a membrane-associated protein involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene is similar in sequence to gamma-glutamyltransferase, but its function is unknown.[3]
References
- ↑ Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA (Oct 1993). "Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes". Genomics 17 (2): 299–305. doi:10.1006/geno.1993.1325. PMID 8104871.
- ↑ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469.
- 1 2 "Entrez Gene: GGTL3 gamma-glutamyltransferase-like 3".
Further reading
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Jikuya H, Takano J, Kikuno R; et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
- Llamazares M, Cal S, Quesada V, López-Otín C (2003). "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.". J. Biol. Chem. 278 (15): 13382–9. doi:10.1074/jbc.M211900200. PMID 12562771.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- He X, Di Y, Li J; et al. (2002). "Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.". Biochem. Biophys. Res. Commun. 297 (3): 528–36. doi:10.1016/S0006-291X(02)02227-1. PMID 12270127.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
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