GGTLA1

Gamma-glutamyltransferase 5
Identifiers
Symbols	GGT5 ; GGL; GGT 5; GGT-REL; GGTLA1
External IDs	OMIM: 137168 MGI: 1346063 HomoloGene: 55802 GeneCards: GGT5 Gene
EC number	2.3.2.2, 3.4.19.13, 3.4.19.14
Gene ontology Molecular function • gamma-glutamyltransferase activity • glutathione hydrolase activity Cellular component • plasma membrane • integral component of membrane • anchored component of external side of plasma membrane Biological process • proteolysis • cellular amino acid metabolic process • leukotriene metabolic process • glutathione metabolic process • glutathione biosynthetic process • inflammatory response • arachidonic acid metabolic process • leukotriene biosynthetic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2687	23887
Ensembl	ENSG00000099998	ENSMUSG00000006344
UniProt	P36269	Q9Z2A9
RefSeq (mRNA)	NM_001099781	NM_011820
RefSeq (protein)	NP_001093251	NP_035950
Location (UCSC)	Chr 22: 24.22 – 24.25 Mb	Chr 10: 75.59 – 75.62 Mb
PubMed search

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.^[1][2][3][4]

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.^[4]

References

1. Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A 88 (14): 6303–7. doi:10.1073/pnas.88.14.6303. PMC 52071. PMID 1676842.
2. Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916.
3. Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469.
4. "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Enoiu M, Aberkane H, Salazar JF; et al. (2000). "Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme.". Free Radic. Biol. Med. 29 (9): 825–33. doi:10.1016/S0891-5849(00)00370-1. PMID 11063908.
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Edelmann L, Pandita RK, Morrow BE (2000). "Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome.". Am. J. Hum. Genet. 64 (4): 1076–86. doi:10.1086/302343. PMC 1377832. PMID 10090893.
• Potdar PD, Andrews KL, Nettesheim P, Ostrowski LE (1997). "Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells.". Am. J. Physiol. 273 (5 Pt 1): L1082–9. PMID 9374738.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.