GIMAP4

GTPase, IMAP family member 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LXX​
Identifiers
Symbols	GIMAP4 ; IAN-1; IAN1; IMAP4; MSTP062
External IDs	OMIM: 608087 MGI: 1349656 HomoloGene: 75084 GeneCards: GIMAP4 Gene
Gene ontology Molecular function • GTP binding Cellular component • cytosol Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55303	107526
Ensembl	ENSG00000133574	ENSMUSG00000054435
UniProt	Q9NUV9	Q99JY3
RefSeq (mRNA)	NM_018326	NM_001243199
RefSeq (protein)	NP_060796	NP_001230128
Location (UCSC)	Chr 7: 150.57 – 150.57 Mb	Chr 6: 48.68 – 48.69 Mb
PubMed search

GTPase IMAP family member 4 is an enzyme that in humans is encoded by the GIMAP4 gene.^[1][2][3]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1.^[3]

References

1. Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F (Oct 2004). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID 15474311.
2. Filen JJ, Filen S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bjorkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R (Jan 2009). "Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation". Mol Cell Proteomics 8 (1): 32–44. doi:10.1074/mcp.M800139-MCP200. PMC 2621005. PMID 18701445.
3. "Entrez Gene: GIMAP4 GTPase, IMAP family member 4".

Further reading

• Dominguez O, Ashhab Y, Sabater L; et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display.". Genomics 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID 9828130.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Stamm O, Krücken J, Schmitt-Wrede HP; et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.". Gene 282 (1-2): 159–67. doi:10.1016/S0378-1119(01)00837-X. PMID 11814688.
• Cambot M, Aresta S, Kahn-Perlès B; et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.". Blood 99 (9): 3293–301. doi:10.1182/blood.V99.9.3293. PMID 11964296.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nitta T, Nasreen M, Seike T; et al. (2006). "IAN family critically regulates survival and development of T lymphocytes.". PLoS Biol. 4 (4): e103. doi:10.1371/journal.pbio.0040103. PMC 1393758. PMID 16509771.