GINS1

GINS complex subunit 1 (Psf1 homolog)
PDB rendering based on 2e9x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E9X​, 2EHO​, 2Q9Q​
Identifiers
Symbols	GINS1 ; PSF1
External IDs	OMIM: 610608 MGI: 1916520 HomoloGene: 44516 GeneCards: GINS1 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • mitotic cell cycle • inner cell mass cell proliferation • DNA strand elongation involved in DNA replication Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9837	69270
Ensembl	ENSG00000101003	ENSMUSG00000027454
UniProt	Q14691	Q9CZ15
RefSeq (mRNA)	NM_021067	NM_001163476
RefSeq (protein)	NP_066545	NP_001156948
Location (UCSC)	Chr 20: 25.41 – 25.45 Mb	Chr 2: 150.91 – 150.93 Mb
PubMed search

DNA replication complex GINS protein PSF1 is a protein that in humans is encoded by the GINS1 gene.^[1][2][3]

References

1. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
2. Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID 8786132.
3. "Entrez Gene: GINS1 GINS complex subunit 1 (Psf1 homolog)".

Further reading

• Kamada K, Kubota Y, Arata T; et al. (2007). "Structure of the human GINS complex and its assembly and functional interface in replication initiation.". Nat. Struct. Mol. Biol. 14 (5): 388–96. doi:10.1038/nsmb1231. PMID 17417653.
• Hayashi R, Arauchi T, Tategu M; et al. (2007). "A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.". Genomics Proteomics Bioinformatics 4 (3): 156–64. doi:10.1016/S1672-0229(06)60028-4. PMID 17127213.
• Ueno M, Itoh M, Kong L; et al. (2005). "PSF1 is essential for early embryogenesis in mice.". Mol. Cell. Biol. 25 (23): 10528–32. doi:10.1128/MCB.25.23.10528-10532.2005. PMC 1291228. PMID 16287864.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.