GLIPR1

GLI pathogenesis-related 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3Q2R​, 3Q2U​
Identifiers
Symbols	GLIPR1 ; CRISP7; GLIPR; RTVP1
External IDs	OMIM: 602692 MGI: 1920940 HomoloGene: 21357 GeneCards: GLIPR1 Gene
Gene ontology Cellular component • extracellular region • plasma membrane • membrane • integral component of membrane Biological process • cellular lipid metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11010	73690
Ensembl	ENSG00000139278	ENSMUSG00000056888
UniProt	P48060	Q9CWG1
RefSeq (mRNA)	NM_006851	NM_028608
RefSeq (protein)	NP_006842	NP_082884
Location (UCSC)	Chr 12: 75.48 – 75.5 Mb	Chr 10: 111.99 – 112 Mb
PubMed search

Glioma pathogenesis-related protein 1 is a protein that in humans is encoded by the GLIPR1 gene.^[1][2][3]

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.^[3]

References

1. Murphy EV, Zhang Y, Zhu W, Biggs J (Aug 1995). "The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors". Gene 159 (1): 131–5. doi:10.1016/0378-1119(95)00061-A. PMID 7607567.
2. Rich T, Chen P, Furman F, Huynh N, Israel MA (Jan 1997). "RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin". Gene 180 (1-2): 125–30. doi:10.1016/S0378-1119(96)00431-3. PMID 8973356.
3. "Entrez Gene: GLIPR1 GLI pathogenesis-related 1 (glioma)".

Further reading

• Szyperski T, Fernández C, Mumenthaler C, Wüthrich K (1998). "Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2262–6. doi:10.1073/pnas.95.5.2262. PMC 19313. PMID 9482873.
• Gingras MC, Margolin JF (2000). "Differential expression of multiple unexpected genes during U937 cell and macrophage differentiation detected by suppressive subtractive hybridization.". Exp. Hematol. 28 (3): 350. doi:10.1016/S0301-472X(00)00149-1. PMID 10658678.
• Ren C, Li L, Goltsov AA; et al. (2002). "mRTVP-1, a novel p53 target gene with proapoptotic activities.". Mol. Cell. Biol. 22 (10): 3345–57. doi:10.1128/MCB.22.10.3345-3357.2002. PMC 133782. PMID 11971968.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ren C, Li L, Yang G; et al. (2004). "RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.". Cancer Res. 64 (3): 969–76. doi:10.1158/0008-5472.CAN-03-2592. PMID 14871827.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ren C, Ren CH, Li L; et al. (2006). "Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.". Genomics 88 (2): 163–72. doi:10.1016/j.ygeno.2006.03.021. PMID 16714093.
• Xiang C, Sarid R, Cazacu S; et al. (2007). "Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.". Biochem. Biophys. Res. Commun. 362 (3): 612–8. doi:10.1016/j.bbrc.2007.08.138. PMID 17825796.
• Chilukamarri L, Hancock AL, Malik S; et al. (2007). "Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors.". Neoplasia 9 (11): 970–8. doi:10.1593/neo.07661. PMC 2077888. PMID 18030365.