GNAS-AS1

GNAS antisense RNA 1
Identifiers
Symbols	GNAS-AS1 ; GNAS-AS; GNAS1AS; GNASAS; NCRNA00075; NESP-AS; NESPAS; SANG
External IDs	OMIM: 610540 GeneCards: GNAS-AS1 Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	149775	n/a
Ensembl	ENSG00000235590	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 20: 58.82 – 58.85 Mb	n/a
PubMed search		n/a

In molecular biology, GNAS antisense RNA (non-protein coding), also known as GNAS-AS1, is a long non-coding RNA.It is antisense to the GNAS gene. It is an imprinted gene, expressed only from the paternal allele, suggesting that it may have a role in suppression of the paternal NESP55 allele encoded by GNAS.^[1]

See also

• Long noncoding RNA

References

1. Hayward BE, Bonthron DT (2000). "An imprinted antisense transcript at the human GNAS1 locus.". Hum Mol Genet 9 (5): 835–41. doi:10.1093/hmg/9.5.835. PMID 10749992.

Further reading

• Tobi EW, Lumey LH, Talens RP; et al. (2009). "DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.". Hum. Mol. Genet. 18 (21): 4046–53. doi:10.1093/hmg/ddp353. PMC 2758137. PMID 19656776.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hayward BE, Bonthron DT (2000). "An imprinted antisense transcript at the human GNAS1 locus.". Hum. Mol. Genet. 9 (5): 835–41. doi:10.1093/hmg/9.5.835. PMID 10749992.
• Wroe SF, Kelsey G, Skinner JA; et al. (2000). "An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3342–6. doi:10.1073/pnas.050015397. PMC 16241. PMID 10716699.
• Li T, Vu TH, Zeng ZL; et al. (2000). "Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus.". Genomics 69 (3): 295–304. doi:10.1006/geno.2000.6337. PMID 11056047.
• Williamson CM, Skinner JA, Kelsey G, Peters J (2002). "Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster.". Mamm. Genome 13 (2): 74–9. doi:10.1007/s00335-001-2102-2. PMID 11889554.