GOLGA1

Golgin A1
PDB rendering based on 2h58.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2H58​
Identifiers
Symbols	GOLGA1 ; golgin-97
External IDs	OMIM: 602502 MGI: 109202 HomoloGene: 68223 ChEMBL: 1075119 GeneCards: GOLGA1 Gene
Gene ontology Molecular function • protein binding Cellular component • Golgi apparatus • trans-Golgi network • Golgi cisterna membrane • intracellular membrane-bounded organelle • perinuclear region of cytoplasm Biological process • protein targeting to Golgi Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2800	76899
Ensembl	ENSG00000136935	ENSMUSG00000026754
UniProt	Q92805	Q9CW79
RefSeq (mRNA)	NM_002077	NM_001290649
RefSeq (protein)	NP_002068	NP_001277578
Location (UCSC)	Chr 9: 124.88 – 124.95 Mb	Chr 2: 39.02 – 39.07 Mb
PubMed search

Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.^[1][2]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome.^[2]

Interactions

GOLGA1 has been shown to interact with ARL1.^[3]

References

1. Griffith KJ, Chan EK, Lung CC, Hamel JC, Guo X, Miyachi K, Fritzler MJ (Oct 1997). "Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjogren's syndrome". Arthritis Rheum 40 (9): 1693–702. doi:10.1002/1529-0131(199709)40:9<1693::AID-ART20>3.0.CO;2-6. PMID 9324025.
2. "Entrez Gene: GOLGA1 golgi autoantigen, golgin subfamily a, 1".
3. Lu, Lei; Hong Wanjin (Sep 2003). "Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell (United States) 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. ISSN 1059-1524. PMC 196566. PMID 12972563.

Further reading

• Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Curr. Biol. 9 (7): 381–4. doi:10.1016/S0960-9822(99)80167-5. PMID 10209123.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lu L, Tai G, Hong W (2005). "Autoantigen Golgin-97, an Effector of Arl1 GTPase, Participates in Traffic from the Endosome to the Trans-Golgi Network". Mol. Biol. Cell 15 (10): 4426–43. doi:10.1091/mbc.E03-12-0872. PMC 519138. PMID 15269279.
• Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form α-helical homodimers". Biochem. J. 388 (Pt 3): 835–41. doi:10.1042/BJ20041810. PMC 1183463. PMID 15654769.
• Lock JG, Hammond LA, Houghton F, et al. (2006). "E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97". Traffic 6 (12): 1142–56. doi:10.1111/j.1600-0854.2005.00349.x. PMID 16262725.
• Alzhanova D, Hruby DE (2007). "A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis". Virology 362 (2): 421–7. doi:10.1016/j.virol.2007.01.003. PMC 2680701. PMID 17276477.