GPAM

Glycerol-3-phosphate acyltransferase, mitochondrial
Identifiers
Symbols	GPAM ; GPAT; GPAT1
External IDs	OMIM: 602395 MGI: 109162 HomoloGene: 7343 GeneCards: GPAM Gene
EC number	2.3.1.15
Gene ontology Molecular function • glycerol-3-phosphate O-acyltransferase activity Cellular component • mitochondrial outer membrane • mitochondrial inner membrane • plasma membrane • integral component of membrane Biological process • fatty acid metabolic process • acyl-CoA metabolic process • phospholipid metabolic process • phosphatidic acid biosynthetic process • response to glucose • CDP-diacylglycerol biosynthetic process • triglyceride biosynthetic process • positive regulation of multicellular organism growth • positive regulation of activated T cell proliferation • cellular lipid metabolic process • small molecule metabolic process • glycerophospholipid biosynthetic process • regulation of cytokine secretion • defense response to virus • fatty acid homeostasis • phospholipid homeostasis • negative regulation of activation-induced cell death of T cells • interleukin-2 secretion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57678	14732
Ensembl	ENSG00000119927	ENSMUSG00000024978
UniProt	Q9HCL2	Q61586
RefSeq (mRNA)	NM_001244949	NM_008149
RefSeq (protein)	NP_001231878	NP_032175
Location (UCSC)	Chr 10: 112.15 – 112.22 Mb	Chr 19: 55.07 – 55.1 Mb
PubMed search

Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene.^[1][2][3]

Glycerol-3-phosphate acyltransferase (GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular triacylglycerol and phospholipid levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the endoplasmic reticulum or mitochondria.[supplied by OMIM]^[3]

References

1. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
2. Yet SF, Lee S, Hahm YT, Sul HS (Oct 1993). "Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase". Biochemistry 32 (36): 9486–9491. doi:10.1021/bi00087a029. PMID 8369314.
3. "Entrez Gene: GPAM glycerol-3-phosphate acyltransferase, mitochondrial".

Further reading

• Skorve J, Ruyter B, Rustan AC, et al. (1990). "Effect of 3- and 4-thia-substituted fatty acids on glycerolipid metabolism and mitochondrial beta-oxidation in rat liver". Biochem. Pharmacol. 40 (9): 2005–2012. doi:10.1016/0006-2952(90)90230-I. PMID 2242030.
• Thomas PD, Poznansky MJ (1990). "Lipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. Effect of iron and copper salts and carbon tetrachloride". J. Biol. Chem. 265 (5): 2684–91. PMID 2303421.
• Welch CL, Xia YR, Edwards PA, et al. (1998). "Assignment of Gpam to distal mouse chromosome 19 by linkage analysis". Mamm. Genome 9 (1): 93–93. doi:10.1007/s003359900694. PMID 9434961.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Igal RA, Wang S, Gonzalez-Baró M, Coleman RA (2001). "Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol". J. Biol. Chem. 276 (45): 42205–42212. doi:10.1074/jbc.M103386200. PMID 11546763.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–381. doi:10.1038/nature02462. PMID 15164054.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.