GPM6B

Glycoprotein M6B
Identifiers
Symbols	GPM6B ; M6B
External IDs	OMIM: 300051 MGI: 107672 HomoloGene: 128189 GeneCards: GPM6B Gene
Gene ontology Molecular function • molecular_function Cellular component • plasma membrane • integral component of membrane • membrane raft Biological process • ossification • nervous system development • protein transport • cell differentiation • positive regulation of bone mineralization • regulation of actin cytoskeleton organization • negative regulation of serotonin uptake • regulation of focal adhesion assembly • extracellular matrix assembly • negative regulation of protein localization to cell surface Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2824	14758
Ensembl	ENSG00000046653	ENSMUSG00000031342
UniProt	Q13491	P35803
RefSeq (mRNA)	NM_001001994	NM_001177955
RefSeq (protein)	NP_001001994	NP_001171426
Location (UCSC)	Chr X: 13.77 – 13.94 Mb	Chr X: 166.24 – 166.39 Mb
PubMed search

Neuronal membrane glycoprotein M6-b is a protein that in humans is encoded by the GPM6B gene.^[1][2]

In melanocytic cells GPM6B gene expression may be regulated by MITF.^[3]

References

1. Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
2. "Entrez Gene: GPM6B glycoprotein M6B".
3. Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Yan Y, Lagenaur C, Narayanan V (1993). "Molecular cloning of M6: identification of a PLP/DM20 gene family.". Neuron 11 (3): 423–31. doi:10.1016/0896-6273(93)90147-J. PMID 8398137.
• Narayanan V, Olinsky S, Dahle E; et al. (1998). "Mutation analysis of the M6b gene in patients with Rett syndrome.". Am. J. Med. Genet. 78 (2): 165–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<165::AID-AJMG13>3.0.CO;2-L. PMID 9674909.
• Yoshida M, Shan WS, Colman DR (1999). "Conserved and divergent expression patterns of the proteolipid protein gene family in the amphibian central nervous system.". J. Neurosci. Res. 57 (1): 13–22. doi:10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E. PMID 10397631.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Werner H, Dimou L, Klugmann M; et al. (2002). "Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes". Mol. Cell. Neurosci. 18 (6): 593–605. doi:10.1006/mcne.2001.1044. PMID 11749036.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Henneke M, Wehner LE, Hennies HC; et al. (2005). "Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome". Am. J. Med. Genet. A 128 (2): 156–8. doi:10.1002/ajmg.a.30068. PMID 15214007.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.