GPRASP1

G protein-coupled receptor associated sorting protein 1
Identifiers
Symbols	GPRASP1 ; GASP; GASP-1; GASP1
External IDs	OMIM: 300417 MGI: 1917418 HomoloGene: 8809 GeneCards: GPRASP1 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytoplasm Biological process • endosome to lysosome transport • G-protein coupled receptor catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9737	67298
Ensembl	ENSG00000198932	ENSMUSG00000043384
UniProt	Q5JY77	Q5U4C1
RefSeq (mRNA)	NM_001099410	NM_001004359
RefSeq (protein)	NP_001092880	NP_001004359
Location (UCSC)	Chr X: 102.65 – 102.66 Mb	Chr X: 135.74 – 135.8 Mb
PubMed search

G-protein coupled receptor-associated sorting protein 1 is a protein that in humans is encoded by the GPRASP1 gene.^[1][2][3]

Interactions

GPRASP1 (gene) has been shown to interact with Delta Opioid receptor.^[4]

References

1. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
2. Simonin F, Karcher P, Boeuf JJ, Matifas A, Kieffer BL (Apr 2004). "Identification of a novel family of G protein-coupled receptor associated sorting proteins". J Neurochem 89 (3): 766–75. doi:10.1111/j.1471-4159.2004.02411.x. PMID 15086532.
3. "Entrez Gene: GPRASP1 G protein-coupled receptor associated sorting protein 1".
4. Whistler, Jennifer L; Enquist Johan; Marley Aaron; Fong Jamie; Gladher Fredrik; Tsuruda Pamela; Murray Stephen R; Von Zastrow Mark (Jul 2002). "Modulation of postendocytic sorting of G protein-coupled receptors". Science (United States) 297 (5581): 615–20. doi:10.1126/science.1073308. PMID 12142540.

Further reading

• Patrie KM, Drescher AJ, Goyal M, et al. (2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes.". J. Am. Soc. Nephrol. 12 (4): 667–77. PMID 11274227.
• Whistler JL, Enquist J, Marley A, et al. (2002). "Modulation of postendocytic sorting of G protein-coupled receptors.". Science 297 (5581): 615–20. doi:10.1126/science.1073308. PMID 12142540.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heydorn A, Søndergaard BP, Ersbøll B, et al. (2005). "A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).". J. Biol. Chem. 279 (52): 54291–303. doi:10.1074/jbc.M406169200. PMID 15452121.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Bartlett SE, Enquist J, Hopf FW, et al. (2005). "Dopamine responsiveness is regulated by targeted sorting of D2 receptors.". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11521–6. doi:10.1073/pnas.0502418102. PMC 1183554. PMID 16049099.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.