GPX3

Glutathione peroxidase 3

PDB rendering based on 2r37.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2R37

Identifiers

Symbols

GPX3 ; GPx-P; GSHPx-3; GSHPx-P

External IDs

OMIM: 138321 MGI: 105102 HomoloGene: 20480 GeneCards: GPX3 Gene

EC number

1.11.1.9

Gene ontology
Molecular function	• glutathione peroxidase activity • protein binding • transcription factor binding • selenium binding
Cellular component	• extracellular region • extracellular space • extracellular exosome
Biological process	• response to reactive oxygen species • response to lipid hydroperoxide • hydrogen peroxide catabolic process • protein homotetramerization • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
151.02 – 151.03 Mb

Chr 11:
54.9 – 54.91 Mb

PubMed search

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.^[1]^[2]^[3]

GPx-3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.^[1]

References

1 2 "Entrez Gene: glutathione peroxidase 3 (plasma)".
↑ Takahashi K, Avissar N, Whitin J, Cohen H (August 1987). "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme". Arch. Biochem. Biophys. 256 (2): 677–86. doi:10.1016/0003-9861(87)90624-2. PMID 3619451.
↑ Chu FF (1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet. Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691.

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Oxidoreductases: peroxidases (EC 1.11)

1.11.1.1-14	Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase

1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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GPX3

References

Further reading