GREB1
| Growth regulation by estrogen in breast cancer 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | GREB1 [] | ||||||||
| External IDs | OMIM: 611736 HomoloGene: 8780 GeneCards: GREB1 Gene | ||||||||
| |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 9687 | 268527 | |||||||
| Ensembl | ENSG00000196208 | ENSMUSG00000036523 | |||||||
| UniProt | Q4ZG55 | Q3UHK3 | |||||||
| RefSeq (mRNA) | NM_014668 | NM_001252071 | |||||||
| RefSeq (protein) | NP_055483 | NP_001239000 | |||||||
| Location (UCSC) |
Chr 2: 11.53 – 11.64 Mb |
Chr 12: 16.67 – 16.8 Mb | |||||||
| PubMed search | |||||||||
Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene.[1]
Function
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]
References
Further reading
- Hnatyszyn HJ, Liu M, Hilger A, Herbert L, Gomez-Fernandez CR, Jorda M, Thomas D, Rae JM, El-Ashry D, Lippman ME (2010). "Correlation of GREB1 mRNA with protein expression in breast cancer: Validation of a novel GREB1 monoclonal antibody". Breast Cancer Research and Treatment 122 (2): 371–80. doi:10.1007/s10549-009-0584-x. PMID 19842031.
- Deschênes J, Bourdeau V, White JH, Mader S (2007). "Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences". Journal of Biological Chemistry 282 (24): 17335–9. doi:10.1074/jbc.C700030200. PMID 17463000.
- Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD (2012). "The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation". PLoS ONE 7 (2): e31593. doi:10.1371/journal.pone.0031593. PMC 3281101. PMID 22359603.
- Pellegrini C, Gori I, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2012). "The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis". Fertility and Sterility 98 (5): 1200–8. doi:10.1016/j.fertnstert.2012.06.056. PMID 22884659.
- Liu M, Wang G, Gomez-Fernandez CR, Guo S (2012). "GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer". PLoS ONE 7 (10): e46410. doi:10.1371/journal.pone.0046410. PMC 3463574. PMID 23056300.
- Nyholt DR, Low SK, Anderson CA, Painter JN, Uno S, Morris AP, MacGregor S, Gordon SD, Henders AK, Martin NG, Attia J, Holliday EG, McEvoy M, Scott RJ, Kennedy SH, Treloar SA, Missmer SA, Adachi S, Tanaka K, Nakamura Y, Zondervan KT, Zembutsu H, Montgomery GW (2012). "Genome-wide association meta-analysis identifies new endometriosis risk loci". Nature Genetics 44 (12): 1355–9. doi:10.1038/ng.2445. PMC 3527416. PMID 23104006.
- Rae JM, Johnson MD, Cordero KE, Scheys JO, Larios JM, Gottardis MM, Pienta KJ, Lippman ME (2006). "GREB1 is a novel androgen-regulated gene required for prostate cancer growth". The Prostate 66 (8): 886–94. doi:10.1002/pros.20403. PMID 16496412.
- Rittié L, Kang S, Voorhees JJ, Fisher GJ (2008). "Induction of collagen by estradiol: Difference between sun-protected and photodamaged human skin in vivo". Archives of Dermatology 144 (9): 1129–40. doi:10.1001/archderm.144.9.1129. PMID 18794456.
- Ghosh MG, Thompson DA, Weigel RJ (2000). "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer". Cancer Research 60 (22): 6367–75. PMID 11103799.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia - version of the Saturday, January 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.