GSPT2

G1 to S phase transition 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSPT2 ; ERF3B; GST2
External IDs OMIM: 300418 MGI: 1316727 HomoloGene: 99786 GeneCards: GSPT2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 23708 14853
Ensembl ENSG00000189369 ENSMUSG00000071723
UniProt Q8IYD1 Q149F3
RefSeq (mRNA) NM_018094 NM_008179
RefSeq (protein) NP_060564 NP_032205
Location (UCSC) Chr X:
51.74 – 51.75 Mb
Chr X:
94.64 – 94.64 Mb
PubMed search

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.[1][2]

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM][2]

Interactions

GSPT2 has been shown to interact with PABPC1.[3]

References

  1. Hansen LL, Jakobsen CG, Justesen J (Jan 2000). "Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping". Cytogenet Cell Genet 86 (3–4): 250–1. doi:10.1159/000015353. PMID 10575220.
  2. 1 2 "Entrez Gene: GSPT2 G1 to S phase transition 2".
  3. Hoshino, S; Imai M; Kobayashi T; Uchida N; Katada T (Jun 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. (UNITED STATES) 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005.

Further reading


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