Glutathione S-transferase Mu 1

Glutathione S-transferase mu 1
PDB rendering based on 1gtu.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GTU​, 1XW6​, 1XWK​, 1YJ6​, 2F3M​
Identifiers
Symbols	GSTM1 ; GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1
External IDs	OMIM: 138350 MGI: 95861 HomoloGene: 121492 ChEMBL: 2081 GeneCards: GSTM1 Gene
EC number	2.5.1.18
Gene ontology Molecular function • glutathione transferase activity • enzyme binding • protein homodimerization activity • glutathione binding Cellular component • cytoplasm • cytosol Biological process • glutathione metabolic process • xenobiotic metabolic process • nitrobenzene metabolic process • xenobiotic catabolic process • small molecule metabolic process • cellular detoxification of nitrogen compound • glutathione derivative biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2944	14863
Ensembl	ENSG00000134184	ENSMUSG00000040562
UniProt	P09488	P15626
RefSeq (mRNA)	NM_000561	NM_008183
RefSeq (protein)	NP_000552	NP_032209
Location (UCSC)	Chr 1: 109.69 – 109.71 Mb	Chr 3: 107.98 – 107.99 Mb
PubMed search

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.^[1]

References

1. "Entrez Gene: GSTM1 glutathione S-transferase M1".

Further reading

• Engel LS, Taioli E, Pfeiffer R, et al. (2002). "Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.". Am. J. Epidemiol. 156 (2): 95–109. doi:10.1093/aje/kwf018. PMID 12117698.
• Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW (2009). "Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes.". Cancer Epidemiol Biomarkers Prev. 18 (11): 2974–8. doi:10.1158/1055-9965.EPI-09-0701. PMC 2777676. PMID 19900941.