GSTT1

Glutathione S-transferase theta 1
PDB rendering based on 2c3n.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2C3N​, 2C3Q​, 2C3T​
Identifiers
Symbol	GSTT1
External IDs	OMIM: 600436 MGI: 107379 HomoloGene: 20235 ChEMBL: 2141 GeneCards: GSTT1 Gene
EC number	2.5.1.18
Gene ontology Molecular function • glutathione transferase activity • glutathione peroxidase activity Cellular component • cytosol • extracellular exosome Biological process • glutathione metabolic process • xenobiotic metabolic process • small molecule metabolic process • oxidation-reduction process • glutathione derivative biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2952	14871
Ensembl	ENSG00000277656	ENSMUSG00000001663
UniProt	P30711	Q64471
RefSeq (mRNA)	NM_000853	NM_008185
RefSeq (protein)	NP_000844	NP_032211
Location (UCSC)	Chr CHR_HSCHR22_1_CTG7: 24.03 – 24.04 Mb	Chr 10: 75.78 – 75.8 Mb
PubMed search

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.^[1]

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[2]

References

1. Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
2. "Entrez Gene: GSTT1 glutathione S-transferase theta 1".