GTF2H5

General transcription factor IIH, polypeptide 5
PDB rendering based on 1ydl.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YDL​, 2JNJ​
Identifiers
Symbols	GTF2H5 ; C6orf175; TFB5; TFIIH; TGF2H5; TTD; TTD-A; TTD3; TTDA; bA120J8.2
External IDs	OMIM: 608780 MGI: 107227 HomoloGene: 45635 GeneCards: GTF2H5 Gene
Gene ontology Molecular function • rDNA binding Cellular component • core TFIIH complex • nucleolus Biological process • nucleotide-excision repair • nucleotide-excision repair, preincision complex assembly • regulation of transcription, DNA-templated • transcription elongation from RNA polymerase I promoter • rRNA processing • cellular response to gamma radiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	404672	66467
Ensembl	ENSG00000272047	ENSMUSG00000034345
UniProt	Q6ZYL4	Q8K2X8
RefSeq (mRNA)	NM_207118	NM_181392
RefSeq (protein)	NP_997001	NP_852057
Location (UCSC)	Chr 6: 158.17 – 158.2 Mb	Chr 17: 6.08 – 6.09 Mb
PubMed search

General transcription factor IIH subunit 5 is a protein that in humans is encoded by the GTF2H5 gene.^[1][2]

Interactions

GTF2H5 has been shown to interact with GTF2H2^[1][3] and XPB.^[1]

References

1. Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (June 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.
2. "Entrez Gene: GTF2H5 general transcription factor IIH, polypeptide 5".
3. Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (November 2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–13. doi:10.1038/81603. PMID 11062469.

Further reading

• Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–13. doi:10.1038/81603. PMID 11062469.
• Coin F, Proietti De Santis L, Nardo T, Zlobinskaya O, Stefanini M, Egly JM (2006). "p8/TTD-A as a repair-specific TFIIH subunit". Mol. Cell 21 (2): 215–26. doi:10.1016/j.molcel.2005.10.024. PMID 16427011.
• Giglia-Mari G, Miquel C, Theil AF, Mari PO, Hoogstraten D, Ng JM, Dinant C, Hoeijmakers JH, Vermeulen W (2006). "Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells". PLoS Biol. 4 (6): e156. doi:10.1371/journal.pbio.0040156. PMC 1457016. PMID 16669699.
• Vitorino M, Coin F, Zlobinskaya O, Atkinson RA, Moras D, Egly JM, Poterszman A, Kieffer B (2007). "Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy". J. Mol. Biol. 368 (2): 473–80. doi:10.1016/j.jmb.2007.02.020. PMID 17350038.