GUK1

Guanylate kinase 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2A1R​, 2A1S​, 3CTR​
Identifiers
Symbols	GUK1 ; GMK
External IDs	OMIM: 139270 MGI: 95871 HomoloGene: 665 ChEMBL: 4989 GeneCards: GUK1 Gene
EC number	2.7.4.8
Gene ontology Molecular function • guanylate kinase activity • ATP binding Cellular component • cytosol Biological process • purine nucleotide metabolic process • dGDP biosynthetic process • nucleobase-containing small molecule interconversion • drug metabolic process • GDP-mannose metabolic process • glycoprotein transport • small molecule metabolic process • ATP metabolic process • GMP metabolic process • dGMP metabolic process • dATP metabolic process • GDP biosynthetic process • nucleotide phosphorylation • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2987	14923
Ensembl	ENSG00000143774	ENSMUSG00000020444
UniProt	Q16774	Q64520
RefSeq (mRNA)	NM_000858	NM_001159410
RefSeq (protein)	NP_000849	NP_001152882
Location (UCSC)	Chr 1: 228.14 – 228.15 Mb	Chr 11: 59.18 – 59.19 Mb
PubMed search

Guanylate kinase is an enzyme that in humans is encoded by the GUK1 gene.^[1][2]

References

1. Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM (Jul 1996). "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation". FEBS Lett 385 (3): 185–188. doi:10.1016/0014-5793(96)00365-1. PMID 8647247.
2. "Entrez Gene: GUK1 guanylate kinase 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brady WA, Kokoris MS, Fitzgibbon M, Black ME (1996). "Cloning, characterization, and modeling of mouse and human guanylate kinases". J. Biol. Chem. 271 (28): 16734–40. doi:10.1074/jbc.271.28.16734. PMID 8663313.
• Boritzki TJ, Jackson RC, Morris HP, Weber G (1981). "Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors". Biochim. Biophys. Acta 658 (1): 102–110. doi:10.1016/0005-2744(81)90253-9. PMID 6260205.
• Dallapiccola B, Lungarotti MS, Falorni A, et al. (1980). "Evidence for the assignment of GUK 1 gene locus to 1q32 leads to q43 segment from gene dosage effect". Ann. Genet. 23 (2): 83–85. PMID 6249178.
• Savitskiĭ IV (1990). "[Increase in 5'-nucleotidase and decrease in guanylate kinase activity in the brain and liver of irradiated rats]". Ukr. Biokhim. Zh. 62 (2): 110–114. PMID 2164269.
• Agarwal KC, Miech RP, Parks RE (1978). "Guanylate kinases from human erythrocytes, hog brain, and rat liver". Meth. Enzymol. Methods in Enzymology 51: 483–490. doi:10.1016/S0076-6879(78)51066-5. ISBN 978-0-12-181951-4. PMID 211390.