GUSB

Glucuronidase, beta
PDB rendering based on 1bhg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BHG​, 3HN3​
Identifiers
Symbols	GUSB ; BG; MPS7
External IDs	OMIM: 611499 MGI: 95872 HomoloGene: 37271 ChEMBL: 2728 GeneCards: GUSB Gene
EC number	3.2.1.31
Gene ontology Molecular function • beta-glucuronidase activity • receptor binding • protein domain specific binding Cellular component • extracellular space • membrane • lysosomal lumen • intracellular membrane-bounded organelle • extracellular exosome Biological process • carbohydrate metabolic process • glycosaminoglycan catabolic process • glycosaminoglycan metabolic process • hyaluronan metabolic process • hyaluronan catabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2990	110006
Ensembl	ENSG00000169919	ENSMUSG00000025534
UniProt	P08236	P12265
RefSeq (mRNA)	NM_000181	NM_010368
RefSeq (protein)	NP_000172	NP_034498
Location (UCSC)	Chr 7: 65.96 – 65.98 Mb	Chr 5: 129.99 – 130 Mb
PubMed search

Beta-glucuronidase is an enzyme that in humans is encoded by the GUSB gene.^[1][2]

See also

• Glucuronidase

References

1. Oshima A, Kyle JW, Miller RD, Hoffmann JW, Powell PP, Grubb JH, Sly WS, Tropak M, Guise KS, Gravel RA (Mar 1987). "Cloning, sequencing, and expression of cDNA for human beta-glucuronidase". Proc Natl Acad Sci U S A 84 (3): 685–9. doi:10.1073/pnas.84.3.685. PMC 304280. PMID 3468507.
2. "Entrez Gene: GUSB glucuronidase, beta".

Further reading

• Bell CE, Sly WS, Brot FE (1977). "Human beta-glucuronidase deficiency mucopolysaccharidosis: identification of cross-reactive antigen in cultured fibroblasts of deficient patients by enzyme immunoassay.". J. Clin. Invest. 59 (1): 97–105. doi:10.1172/JCI108627. PMC 333336. PMID 401508.
• Tanaka J, Gasa S, Sakurada K, et al. (1992). "Characterization of the subunits and sugar moiety of human placental and leukemic beta-glucuronidase.". Biol. Chem. Hoppe-Seyler 373 (1): 57–62. doi:10.1515/bchm3.1992.373.1.57. PMID 1311180.
• Wolfe JH, Sands MS, Barker JE, et al. (1993). "Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.". Nature 360 (6406): 749–53. doi:10.1038/360749a0. PMID 1465145.
• Tomatsu S, Fukuda S, Sukegawa K, et al. (1991). "Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity.". Am. J. Hum. Genet. 48 (1): 89–96. PMC 1682743. PMID 1702266.
• Shipley JM, Miller RD, Wu BM, et al. (1991). "Analysis of the 5' flanking region of the human beta-glucuronidase gene.". Genomics 10 (4): 1009–18. doi:10.1016/0888-7543(91)90192-H. PMID 1916806.
• Ono M, Taniguchi N, Makita A, et al. (1988). "Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.". J. Biol. Chem. 263 (12): 5884–9. PMID 2833520.
• Guise KS, Korneluk RG, Waye J, et al. (1985). "Isolation and expression in Escherichia coli of a cDNA clone encoding human beta-glucuronidase.". Gene 34 (1): 105–10. doi:10.1016/0378-1119(85)90300-2. PMID 3924735.
• Ho YC, Ho LH, Ho KJ (1985). "Human hepatic beta-glucuronidase: an enzyme kinetic study.". Enzyme 33 (1): 9–17. PMID 3987656.
• Shipley JM, Klinkenberg M, Wu BM, et al. (1993). "Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes.". Am. J. Hum. Genet. 52 (3): 517–26. PMC 1682147. PMID 7680524.
• Vervoort R, Lissens W, Liebaers I (1994). "Molecular analysis of a patient with hydrops fetalis caused by beta-glucuronidase deficiency, and evidence for additional pseudogenes.". Hum. Mutat. 2 (6): 443–5. doi:10.1002/humu.1380020604. PMID 8111412.
• Wu BM, Sly WS (1994). "Mutational studies in a patient with the hydrops fetalis form of mucopolysaccharidosis type VII.". Hum. Mutat. 2 (6): 446–57. doi:10.1002/humu.1380020605. PMID 8111413.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Moullier P, Bohl D, Heard JM, Danos O (1993). "Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts". Nat. Genet. 4 (2): 154–9. doi:10.1038/ng0693-154. PMID 8348154.
• Shipley JM, Grubb JH, Sly WS (1993). "The role of glycosylation and phosphorylation in the expression of active human beta-glucuronidase". J. Biol. Chem. 268 (16): 12193–8. PMID 8505339.
• Nishimura Y, Kato K, Himeno M (1996). "Biochemical characterization of liver microsomal, Golgi, lysosomal, and serum beta-glucuronidases in dibutyl phosphate-treated rats". J. Biochem. 118 (1): 56–66. PMID 8537326.
• Jain S, Drendel WB, Chen ZW, et al. (1996). "Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs". Nat. Struct. Biol. 3 (4): 375–81. doi:10.1038/nsb0496-375. PMID 8599764.
• Vervoort R, Islam MR, Sly WS, et al. (1996). "Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII". Am. J. Hum. Genet. 58 (3): 457–71. PMC 1914559. PMID 8644704.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dentino AR, Raj PA, De Nardin E (1997). "Subtle differences between human and rabbit neutrophil receptors shown by the secretagogue activity of constrained formyl peptides". Arch. Biochem. Biophys. 337 (2): 267–74. doi:10.1006/abbi.1996.9791. PMID 9016822.