GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]

GVD regimen consists of three drugs:

  1. (G)emcitabine
  2. (V)inorelbine
  3. (D)oxil - pegylated liposomal formulation of doxorubicin

Dosing

Drug Dose in transplant-naive patients Dose in post-transplant patients Mode Days
(G)emcitabine 1000 mg/m2 800 mg/m2 IV infusion Days 1, 8
(V)inorelbine 20 mg/m2 15 mg/m2 IV bolus Days 1, 8
(D)oxil 15 mg/m2 10 mg/m2 IV infusion Days 1, 8

Repeated every 21 day (3 weeks).

References

  1. ↑ Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804
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