GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]

GVD regimen consists of three drugs:

  1. (G)emcitabine
  2. (V)inorelbine
  3. (D)oxil - pegylated liposomal formulation of doxorubicin

Dosing

Drug Dose in transplant-naive patients Dose in post-transplant patients Mode Days
(G)emcitabine 1000 mg/m2 800 mg/m2 IV infusion Days 1, 8
(V)inorelbine 20 mg/m2 15 mg/m2 IV bolus Days 1, 8
(D)oxil 15 mg/m2 10 mg/m2 IV infusion Days 1, 8

Repeated every 21 day (3 weeks).

References

This article is issued from Wikipedia - version of the Thursday, September 18, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.