GZMH
| Granzyme H (cathepsin G-like 2, protein h-CCPX) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | GZMH ; CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2 | ||||||||||||
| External IDs | OMIM: 116831 MGI: 109253 HomoloGene: 133275 GeneCards: GZMH Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2999 | 14941 | |||||||||||
| Ensembl | ENSG00000100450 | ENSMUSG00000059256 | |||||||||||
| UniProt | P20718 | P11033 | |||||||||||
| RefSeq (mRNA) | NM_001270780 | NM_010372 | |||||||||||
| RefSeq (protein) | NP_001257709 | NP_034502 | |||||||||||
| Location (UCSC) |
Chr 14: 24.61 – 24.61 Mb |
Chr 14: 56.13 – 56.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Granzyme H is a protein that in humans is encoded by the GZMH gene.[1][2]
References
- ↑ Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene". Int Immunol 3 (1): 57–66. doi:10.1093/intimm/3.1.57. PMID 2049336.
- ↑ "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)".
Further reading
- Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells.". Trends Immunol. 28 (9): 373–5. doi:10.1016/j.it.2007.08.001. PMID 17766182.
- Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence.". Nature 274 (5671): 603–5. doi:10.1038/274603a0. PMID 209336.
- Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.". J. Biol. Chem. 266 (10): 6152–8. PMID 2007574.
- Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family". Biochemistry 29 (17): 4042–9. doi:10.1021/bi00469a003. PMID 2193684.
- Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 960–3. doi:10.1073/pnas.87.3.960. PMC 53389. PMID 2300587.
- Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)". Tissue Antigens 35 (5): 220–8. doi:10.1111/j.1399-0039.1990.tb01787.x. PMID 2402757.
- MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice". Blood 93 (3): 963–73. PMID 9920846.
- Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes". J. Biol. Chem. 274 (43): 30468–73. doi:10.1074/jbc.274.43.30468. PMID 10521426.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C". Blood 101 (8): 3093–101. doi:10.1182/blood-2002-08-2485. PMID 12515723.
- Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes". J. Biol. Chem. 279 (25): 26581–7. doi:10.1074/jbc.M312481200. PMID 15069086.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition". EMBO J. 26 (8): 2148–57. doi:10.1038/sj.emboj.7601650. PMC 1852776. PMID 17363894.
- Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program". Blood 110 (2): 544–52. doi:10.1182/blood-2006-10-051649. PMID 17409270.
This article is issued from Wikipedia - version of the Monday, July 27, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.