Gabriel Bertrand
| Gabriel Bertrand | |
|---|---|
| Born |
May 17, 1867 Paris |
| Died |
June 20, 1962 (aged 95) Paris |
| Nationality | French |
| Institutions | Institut Pasteur |
| Doctoral advisor | Émile Duclaux |
| Other academic advisors | Edmond Frémy |
| Known for |
concepts of oxidase and trace elements Bertrand's rule |
Gabriel Bertrand (born 17 May 1867 in Paris, died 20 June 1962 in Paris) was a French pharmacologist, biochemist and bacteriologist.
Bertrand introduced into biochemistry both the term “oxidase” and the concept of trace elements.
The laccase, a polyphenol oxidase and an enzyme oxidating urishiol and laccol obtained from the lacquer tree, was first studied by Gabriel Bertrand[1] in 1894.[2] In 1904, Casimir Funk earned his Ph.D. after completing his dissertation on how to prepare two stilbene dyes, brazilin and hematoxylin. He then went to the Pasteur Institute in Paris, where he studied organic bases and amino acids under Gabriel Bertrand. During his time in Paris, Funk experimented with laccol, a phenol that caused him to suffer painful swelling.
Bertrand's rule is the fact that the dose–response curve for many micronutrients is non-monotonic, having an initial stage of increasing benefits with increased intake, followed by increasing costs as excesses become toxic.[3]
In 1894, with Césaire Phisalix, he developed an antivenom for use against snake bites.[4]
Bertrand was made a member of the Académie Nationale de Médecine in 1931. In 1932 he became foreign member of the Royal Netherlands Academy of Arts and Sciences.[5]
References
- ↑ Gabriel Bertrand on isimabomba.free.fr (French)
- ↑ Science and civilisation in China: Chemistry and chemical ..., Volume 5, Part 4 By Joseph Needham, Ping-Yü Ho, Gwei-Djen Lu and Nathan Sivin, p. 209
- ↑ Does Bertrand's rule apply to macronutrients? D Raubenheimer, K.P Lee and S.J Simpson, Proc Biol Sci. 2005 November 22; 272(1579): 2429–2434, doi:10.1098/rspb.2005.3271
- ↑ Le Musee Pasteur Césaire et Marie PHISALIX, deux chercheurs comtois
- ↑ "G. Bertrand (1867 - 1962)". Royal Netherlands Academy of Arts and Sciences. Retrieved 20 July 2015.
External links
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