Gene transfer agent-release holin family

Gene transfer agent-release holins (GTA-Hol, TC# 1.E.54) are holins which are believed to facilitate the lysis-dependent release of a gene transfer agent. Particularly the gene transfer agent of Rhodobacter capsulatus (RcGTA), which is known to be a bacteriophage-like genetic element that induces horizontal gene transfer. The promoter of the RcGTA gene was identified by Westbye et al. in 2013.^[1] A representative list of members belonging to the GTA-Hol family can be found in the Transporter Classification Database with homologues found in proteobacteria and caudovirales.^[1][2]

See also

• Gene transfer agent
• Lysin

References

1. Westbye, A. B.; Leung, M. M.; Florizone, S. M.; Taylor, T. A.; Johnson, J. A.; Fogg, P. C.; Beatty, J. T. (2013-11-01). "Phosphate concentration and the putative sensor kinase protein CckA modulate cell lysis and release of the Rhodobacter capsulatus gene transfer agent". Journal of Bacteriology 195 (22): 5025–5040. doi:10.1128/JB.00669-13. ISSN 1098-5530. PMC: 3811591. PMID 23995641.
2. "1.E.54 The Gene Transfer Agent-release Holin (GTA-Hol) Family". TCDB. Retrieved 2016-03-29.

Further reading

• Biers, Erin J.; Wang, Kui; Pennington, Catherine; Belas, Robert; Chen, Feng; Moran, Mary Ann (2008-05-15). "Occurrence and Expression of Gene Transfer Agent Genes in Marine Bacterioplankton". Applied and Environmental Microbiology 74 (10): 2933–2939.doi:10.1128/AEM.02129-07. ISSN 0099-2240.PMC 2394915. PMID 18359833.
• Lang, Andrew S.; Zhaxybayeva, Olga; Beatty, J. Thomas. "Gene transfer agents: phage-like elements of genetic exchange". Nature Reviews Microbiology. doi:10.1038/nrmicro2802. PMC: 3626599. PMID 22683880.
• Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671.doi:10.1016/j.bbamem.2013.07.004. PMC 3788059.PMID 23856191.
• Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology 197(1): 7–17. doi:10.1128/JB.02046-14. ISSN 0021-9193.PMC 4288690. PMID 25157079.
• Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology 54: 799–825.doi:10.1146/annurev.micro.54.1.799. ISSN 0066-4227.PMID 11018145.

As of 2016-03-29, this article is derived in whole or in part from the Transporter Classification Database. The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "1.E.54. The Gene Transfer Agent-release Holin (GTA-Hol) Family".