Ghrelin O-acyltransferase
| Membrane bound O-acyltransferase domain containing 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MBOAT4 ; FKSG89; GOAT; OACT4 | ||||||||||||
| External IDs | OMIM: 611940 HomoloGene: 19272 GeneCards: MBOAT4 Gene | ||||||||||||
| EC number | 2.3.1.- | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 619373 | 234155 | |||||||||||
| Ensembl | ENSG00000177669 | ENSMUSG00000071113 | |||||||||||
| UniProt | Q96T53 | P0C7A3 | |||||||||||
| RefSeq (mRNA) | NM_001100916 | NM_001126314 | |||||||||||
| RefSeq (protein) | NP_001094386 | NP_001119786 | |||||||||||
| Location (UCSC) |
Chr 8: 30.13 – 30.14 Mb |
Chr 8: 34.12 – 34.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Ghrelin O-acyltransferase also known as membrane bound O-acyltransferase domain containing 4 is an enzyme that in humans is encoded by the MBOAT4 gene.[1] It is homologous to other membrane-bound O-acyltransferases.
References
Further Reading
- Gómez, R; Lago, F; Gómez-Reino, J. J.; Dieguez, C; Gualillo, O (2009). "Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes". Arthritis & Rheumatism 60 (6): 1704–9. doi:10.1002/art.24522. PMID 19479831.
- Gutierrez, J. A.; Solenberg, P. J.; Perkins, D. R.; Willency, J. A.; Knierman, M. D.; Jin, Z; Witcher, D. R.; Luo, S; Onyia, J. E.; Hale, J. E. (2008). "Ghrelin octanoylation mediated by an orphan lipid transferase". Proceedings of the National Academy of Sciences 105 (17): 6320–5. doi:10.1073/pnas.0800708105. PMC 2359796. PMID 18443287.
- Rodríguez, A; Gómez-Ambrosi, J; Catalán, V; Rotellar, F; Valentí, V; Silva, C; Mugueta, C; Pulido, M. R.; Vázquez, R; Salvador, J; Malagón, M. M.; Colina, I; Frühbeck, G (2012). "The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes". Diabetologia 55 (11): 3038–50. doi:10.1007/s00125-012-2671-5. PMID 22869322.
- Takahashi, T; Ida, T; Sato, T; Nakashima, Y; Nakamura, Y; Tsuji, A; Kojima, M (2009). "Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid". Journal of Biochemistry 146 (5): 675–82. doi:10.1093/jb/mvp112. PMID 19628676.
- Lim, C. T.; Kola, B; Grossman, A; Korbonits, M (2011). "The expression of ghrelin O-acyltransferase (GOAT) in human tissues". Endocrine journal 58 (8): 707–10. doi:10.1507/endocrj.k11e-117. PMID 21646729.
- Liu, B; Garcia, E. A.; Korbonits, M (2011). "Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes". Peptides 32 (11): 2191–207. doi:10.1016/j.peptides.2011.09.006. PMID 21930173.
- Heppner, K. M.; Tong, J; Kirchner, H; Nass, R; Tschöp, M. H. (2011). "The ghrelin O-acyltransferase-ghrelin system: A novel regulator of glucose metabolism". Current Opinion in Endocrinology, Diabetes and Obesity 18 (1): 50–5. doi:10.1097/MED.0b013e328341e1d3. PMID 21150588.
- Müller, T. D.; Tschöp, M. H.; Jarick, I; Ehrlich, S; Scherag, S; Herpertz-Dahlmann, B; Zipfel, S; Herzog, W; De Zwaan, M; Burghardt, R; Fleischhaker, C; Klampfl, K; Wewetzer, C; Herpertz, S; Zeeck, A; Tagay, S; Burgmer, M; Pfluger, P. T.; Scherag, A; Hebebrand, J; Hinney, A (2011). "Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa". Journal of Psychiatric Research 45 (5): 706–11. doi:10.1016/j.jpsychires.2010.10.001. PMID 21035823.
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