CCDC88A

Coiled-coil domain containing 88A
Identifiers
Symbols	CCDC88A ; APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212
External IDs	OMIM: 609736 MGI: 1925177 HomoloGene: 41180 GeneCards: CCDC88A Gene
Gene ontology Molecular function • actin binding • microtubule binding • phosphatidylinositol binding • protein homodimerization activity • protein kinase B binding Cellular component • endoplasmic reticulum • Golgi apparatus • cytosol • plasma membrane • membrane • cytoplasmic membrane-bounded vesicle • lamellipodium • cytoplasmic vesicle Biological process • regulation of protein phosphorylation • DNA replication • regulation of DNA replication • regulation of neuron projection development • cell migration • lamellipodium assembly • TOR signaling • activation of protein kinase B activity • regulation of actin cytoskeleton organization • regulation of cell proliferation • membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55704	108686
Ensembl	ENSG00000115355	ENSMUSG00000032740
UniProt	Q3V6T2	Q5SNZ0
RefSeq (mRNA)	NM_001135597	NM_176841
RefSeq (protein)	NP_001129069	NP_789811
Location (UCSC)	Chr 2: 55.29 – 55.42 Mb	Chr 11: 29.37 – 29.51 Mb
PubMed search

Girdin is a protein that in humans is encoded by the CCDC88A gene.^[1][2][3]

References

1. Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.
2. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.
3. "Entrez Gene: KIAA1212 KIAA1212".

External links

• DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009

Further reading

• Kitamura T, Asai N, Enomoto A; et al. (2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.". Nat. Cell Biol. 10 (3): 329–37. doi:10.1038/ncb1695. PMID 18264090.
• Enomoto A, Murakami H, Asai N; et al. (2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE.". Dev. Cell 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
• Simpson F, Martin S, Evans TM; et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1.". Traffic 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.