Glucuronide
Morphine-6-glucuronide, a major metabolite of morphine
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.[1] The glucuronides belong to the glycosides.
Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.
Examples
- Miquelianin (Quercetin 3-O-glucuronide)
- Morphine-6-glucuronide
- Ezetimibe (Prodrug)
- Scutellarein-7-glucuronide
References
- ↑ The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company
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