Glutamine—pyruvate transaminase

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:pyruvate aminotransferase. Other names in common use include glutaminase II, L-glutamine transaminase L, and glutamine-oxo-acid transaminase. This enzyme participates in glutamate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1V2D, 1V2E, and 1V2F.

References

Cooper JL, Meister A (1972). "Isolation and properties of highly purified glutamine transaminase". Biochemistry. 11 (5): 661–71. doi:10.1021/bi00755a001. PMID 5059882.
MEISTER A (1954). "Studies on the mechanism and specificity of the glutamine-alpha-keto acid transamination-deamidation reaction". J. Biol. Chem. 210 (1): 17–35. PMID 13201566.

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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