Glutamyl-tRNA reductase

glutamyl-tRNA reductase
Identifiers
EC number	1.2.1.70
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

A glutamyl-tRNA reductase (EC 1.2.1.70) is an enzyme that catalyzes the chemical reaction

L-glutamate 1-semialdehyde + NADP⁺ + tRNAGlu $\rightleftharpoons$ L-glutamyl-tRNAGlu + NADPH + H⁺

The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP⁺, and tRNA(Glu), whereas its 3 products are L-glutamyl-tRNA(Glu), NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming). This enzyme participates in porphyrin and chlorophyll metabolism.

References

• Von Wettstein D, Gough S, Kannangara CG (1995). "Chlorophyll Biosynthesis". Plant. Cell. 7 (7): 1039–1057. doi:10.1105/tpc.7.7.1039. PMC 160907. PMID 12242396.
• Pontoppidan B, Kannangara CG (1994). "Purification and partial characterisation of barley glutamyl-tRNA(Glu) reductase, the enzyme that directs glutamate to chlorophyll biosynthesis". Eur. J. Biochem. 225 (2): 529–37. doi:10.1111/j.1432-1033.1994.00529.x. PMID 7957167.
• Heinz DW, Inokuchi H, Soll D, Jahn D (2002). "Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate". J. Biol. Chem. 277 (50): 48657–63. doi:10.1074/jbc.M206924200. PMID 12370189.