Glutathione amide reductase

Glutathione amide reductase (EC 1.8.1.16, GAR) is an enzyme with systematic name glutathione amide:NAD⁺ oxidoreductase.^[1]^[2] This enzyme catalyses the following chemical reaction

2 glutathione amide + NAD⁺

\rightleftharpoons

glutathione amide disulfide + NADH + H⁺

Glutathione amide reductase is a dimeric flavoprotein (FAD).

References

↑ Vergauwen, B., Pauwels, F., Jacquemotte, F., Meyer, T.E., Cusanovich, M.A., Bartsch, R.G. and Van Beeumen, J.J. (2001). "Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". J. Biol. Chem. 276: 20890–20897. doi:10.1074/jbc.M102026200. PMID 11399772.
↑ Vergauwen, B., Van Petegem, F., Remaut, H., Pauwels, F. and Van Beeumen, J.J. (2002). "Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 2): 339–340. doi:10.1107/s0907444901020303. PMID 11807270.

External links

Glutathione amide reductase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: sulfur oxidoreductases (EC 1.8)

1.8.1: NAD or NADP	Dihydrolipoamide dehydrogenase Glutathione reductase Thioredoxin reductase

1.8.2: cytochrome	Sulfite dehydrogenase Thiosulfate dehydrogenase

1.8.3: oxygen	Sulfite oxidase

1.8.4: disulfide	Glutathione—homocystine transhydrogenase

1.8.5: quinone	Glutathione dehydrogenase (ascorbate)

1.8.98: Other, known	CoB—CoM heterodisulfide reductase

1.8.99: Other	Sulfite reductase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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