Glycine oxidase

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Glycine oxidase (EC 1.4.3.19) is an enzyme with systematic name glycine:oxygen oxidoreductase (deaminating).^[1]^[2] This enzyme catalyses the following chemical reaction

glycine + H₂O + O₂

\rightleftharpoons

glyoxylate + NH₃ + H₂O₂ (overall reaction)

(1a) glycine + O₂

\rightleftharpoons

2-iminoacetate + H₂O₂

(1b) 2-iminoacetate + H₂O

\rightleftharpoons

glyoxylate + NH₃

This flavoenzyme containing non-covalently bound FAD.

References

↑ Job, V., Marcone, G.L., Pilone, M.S. and Pollegioni, L. (2002). "Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein". J. Biol. Chem. 277 (9): 6985–6993. doi:10.1074/jbc.M111095200. PMID 11744710.
↑ Nishiya, Y. and Imanaka, T. (1998). "Purification and characterization of a novel glycine oxidase from Bacillus subtilis". FEBS Lett. 438 (3): 263–266. doi:10.1016/s0014-5793(98)01313-1. PMID 9827558.

External links

Glycine oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)

CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases

1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)

1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))

1.4.4: disulfide acceptor	Glycine cleavage system

1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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