Glypican 2

Glypican 2
Identifiers
Symbols	GPC2 ; DKFZp547M109; FLJ38962
External IDs	MGI: 1919201 HomoloGene: 17657 GeneCards: GPC2 Gene
Gene ontology Molecular function • heparan sulfate proteoglycan binding Cellular component • proteinaceous extracellular matrix • extracellular space • endoplasmic reticulum • Golgi lumen • plasma membrane • anchored component of membrane • lysosomal lumen Biological process • retinoid metabolic process • carbohydrate metabolic process • glycosaminoglycan biosynthetic process • glycosaminoglycan catabolic process • smoothened signaling pathway • phototransduction, visible light • neuron differentiation • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221914	71951
Ensembl	ENSG00000213420	ENSMUSG00000029510
UniProt	Q8N158	Q8BKV1
RefSeq (mRNA)	NM_152742	NM_172412
RefSeq (protein)	NP_689955	NP_766000
Location (UCSC)	Chr 7: 100.17 – 100.18 Mb	Chr 5: 138.27 – 138.28 Mb
PubMed search

Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene.^[1][2]

Function

Cerebroglycan is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.^[3] Cerebroglycan has especially high affinity for laminin-1.^[4]

See also

• Glypican

References

1. Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". J. Cell Biol. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498.
2. "Entrez Gene: GPC2 glypican 2".
3. Ivins JK, Litwack ED, Kumbasar A, Stipp CS, Lander AD (April 1997). "Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones". Dev. Biol. 184 (2): 320–332. doi:10.1006/dbio.1997.8532. PMID 9133438.
4. Herndon ME, Stipp CS, Lander AD (February 1999). "Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding". Glycobiology 9 (2): 143–155. doi:10.1093/glycob/9.2.143. PMID 9949192.

External links

• GPC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)