Granzyme A

Granzyme A
Identifiers
EC number	3.4.21.78
CAS number	143180-73-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Granzyme A (EC 3.4.21.78, CTLA3, HuTPS, T-cell associated protease 1, cytotoxic T lymphocyte serine protease, TSP-1, T-cell derived serine proteinase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-, -Lys- >> -Phe- in small molecule substrates

This enzyme is present in cytotoxic T lymphocyte granules.

See also

• GZMA

References

1. Simon, M.M., Hoschützky, H., Fruth, U., Simon, H.-G. and Kramer, M.D. (1986). "Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes". EMBO J. 5 (12): 3267–3274. PMID 3545816.
2. Gershenfeld, H.K., Hershberger, R.J., Shows, T.B. and Weissman, I.L. (1988). "Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease". Proc. Natl. Acad. Sci. USA 85: 1184–1188. doi:10.1073/pnas.85.4.1184. PMC 279731. PMID 3257574.
3. Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. (1991). "Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins". Biochemistry 30 (8): 2217–2227. doi:10.1021/bi00222a027. PMID 1998680.

External links

• Granzyme A at the US National Library of Medicine Medical Subject Headings (MeSH)